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HRID403677

反应详情

EQUATION

反应方程式

HRID 403677 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)CCN=C=O
HCID2733373

ethyl 3-isocyanatopropanoate

C6H9NO3

结构：COc1c(I)cc(N)cc1C(C)(C)C
HCID57419443

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)CCNC(=O)Nc1cc(I)c(OC)c(C(C)(C)C)c1
HCID66700079

未命名化合物

收率 83%

PROCEDURE

实验过程

3-tert-Butyl-5-iodo-4-methoxyaniline (305 mg, 1 mmol) and ethyl 3-isocyanatopropionate were reacted in the same manner as Example 15 Part A and purified on an Isco 40 g silica cartridge eluting with ethyl acetate/hexane (0% to 25%) to give the title compound (373 mg, 83%).

WORKUP

后处理

  1. custompurified on an Isco 40 g silica cartridge
  2. washeluting with ethyl acetate/hexane (0% to 25%)