Triethylamine → HCID 131731439, compound

HRID 403678Notes

Reaction equation

HRID 403678 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:9]=[C:10]([I:14])[C:11]=1[O:12][CH3:13])[NH2:8])([CH3:4])([CH3:3])[CH3:2].Cl[C:16]([O:18][CH2:19][CH2:20][Cl:21])=[O:17].C(N(CC)CC)C>ClCCl>[Cl:21][CH2:20][CH2:19][O:18][C:16](=[O:17])[NH:8][C:7]1[CH:9]=[C:10]([I:14])[C:11]([O:12][CH3:13])=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 123052-Chloroethyl chloroformateHCID 57419443HCID 57419443, compound

Product 1

HCID 131731439HCID 131731439, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-tert-butyl-5-iodo-4-methoxyaniline (0.305 g, 1.0 mmol) in dichloromethane (5.00 mL) was added 2-chloroethyl chloroformate (0.143 g, 1.000 mmol) and triethylamine (0.279 mL, 2.0 mmol) to give a solution. The mixture was stirred for 3 hours and concentrated to give the title compound that was used without purification.

Workup

  1. customto give a solution
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-f2a0510b75e94cfa91a60cec3ddd3372
Source dataset
uspto-grants-2014_06
Patent number
US08748443B2

Reaction notes

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