Benzonitrile, 4-isothiocyanato- → HCID 131731455, compound

HRID 403748Notes

Reaction equation

HRID 403748 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[S:35])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:25]=[C:24]3[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[C:23]3=[O:26])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1.[NH2:36][C:37]1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.C(C1C=CC(N=C=S)=CC=1)#N>>[C:37]([C:6]1[CH:5]=[CH:4][C:3]([NH:8][C:9](=[S:35])[NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:25]=[C:24]4[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:33])[CH3:34])[C:28]([O:30][CH3:31])=[O:29])[C:23]4=[O:26])=[CH:19][CH:18]=3)=[CH:15][CH:16]=2)=[CH:2][CH:7]=1)#[N:36]

Participants

4

Reactant 3

HCID 17626Benzonitrile, 4-isothiocyanato-HCID 53303391(S)-Methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731455HCID 131731455, compound

Procedure

The compound of example 67 was prepared analogous to compound of example 51 by reaction of compound of example 6 with 4-cyanophenyl isothiocyanate. The compound of example 67 was used directly without isolation for the preparation of compound of example 66.

Sources & evidence

ORD record
ord-d35a9f11eb13423aa793f31a0c6e118a
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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