(S)-3-Methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid → (S)-3-Methyl-2-(1-oxo-6-(4-(phenylmethylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid

HRID 403769Notes

Reaction equation

HRID 403769 reaction equation
CC(C)[C@H](N1CC2C(=CC(C3C=CC(NS(C4C=CC=CC=4)(=O)=O)=CC=3)=CC=2)C1=O)C(O)=O.[CH3:34][CH:35]([CH3:68])[C@H:36]([N:41]1[CH2:49][C:48]2[C:43](=[CH:44][C:45]([C:50]3[CH:55]=[CH:54][C:53]([NH:56][S:57]([CH2:60][C:61]4[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=4)(=[O:59])=[O:58])=[CH:52][CH:51]=3)=[CH:46][CH:47]=2)[C:42]1=[O:67])[C:37]([O:39]C)=[O:38]>>[CH3:34][CH:35]([CH3:68])[C@H:36]([N:41]1[CH2:49][C:48]2[C:43](=[CH:44][C:45]([C:50]3[CH:51]=[CH:52][C:53]([NH:56][S:57]([CH2:60][C:61]4[CH:62]=[CH:63][CH:64]=[CH:65][CH:66]=4)(=[O:59])=[O:58])=[CH:54][CH:55]=3)=[CH:46][CH:47]=2)[C:42]1=[O:67])[C:37]([OH:39])=[O:38]

Participants

3

Reactant 2

HCID 67306729(S)-3-Methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acidHCID 131731464(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(phenylmethylsulfonamido)phenyl)isoindolin-2-yl)butanoate

Product 1

HCID 67307420(S)-3-Methyl-2-(1-oxo-6-(4-(phenylmethylsulfonamido)phenyl)isoindolin-2-yl)butanoic acidYield 96%

Procedure

The compound of example 94 was prepared analogous to compound of example 78 by hydrolysis of compound of example 93.

Sources & evidence

ORD record
ord-7b9b79fed55b4faf833b83dee0f44320
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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