Benzoyl chloride, 3-chloro- → (S)-Methyl 2-(6-(4-(3-chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403779Notes

Reaction equation

HRID 403779 reaction equation
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[Cl:59]C1C=C(C=CC=1)C(Cl)=O>>[Cl:59][C:6]1[CH:7]=[C:2]([CH:3]=[CH:4][CH:5]=1)[C:1]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)=[O:8]

Participants

4

Reactant 3

HCID 69252Benzoyl chloride, 3-chloro-HCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731468(S)-Methyl 2-(6-(4-(3-chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Procedure

The compound of example 107 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 3-chlorobenzoyl chloride. The compound of example 107 was used directly without isolation for the preparation of compound of example 108.

Sources & evidence

ORD record
ord-db7807b7ba444021b2ce9a53caf1e876
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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