HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride, 3-chloro- → (S)-Methyl 2-(6-(4-(3-chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride, 3-chloro- | HCID 69252 | — |
| Reactant | (S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 123625862 | — |
| Reactant | (S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731441 | — |
| Product | (S)-Methyl 2-(6-(4-(3-chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731468 | — |
Reaction Steps
The compound of example 107 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 3-chlorobenzoyl chloride. The compound of example 107 was used directly without isolation for the preparation of compound of example 108.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-db7807b7ba444021b2ce9a53caf1e876 |
| Source note | uspto-grants-2014_06 |