HRID403832

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2795466

5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl chloride

C15H19ClO

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID123625862

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O

HCID131731441

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccc5c(c4)C(C)(C)CCC5(C)C)cc3)cc2C1=O

HCID123143580

未命名化合物

收率 76%

PROCEDURE

实验过程

The compound of example 175 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 5,5,8,8-tetramethyl-5,6,7,8-tetra hydronaphthalene-2-carbonyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e1fc3d8b59c24374b434c357172316a0
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44](CN([C@@H](C(C)C)C(OC)=O)[C:47]3=O)=CC=2)=[CH:37]C=1.CC1(C)CCC(C)(C)C2C=C(C(Cl)=O)C=CC1=2>>[CH3:32][CH:31]([CH3:33])[C@H:26]([N:21]1[CH2:20][C:19]2[C:23](=[CH:24][C:16]([C:13]3[CH:12]=[CH:11][C:10]([NH:9][C:1]([C:2]4[CH:3]=[CH:4][C:5]5[C:48]([CH3:44])([CH3:47])[CH2:49][CH2:41][C:38]([CH3:39])([CH3:37])[C:6]=5[CH:7]=4)=[O:8])=[CH:15][CH:14]=3)=[CH:17][CH:18]=2)[C:22]1=[O:25])[C:27]([O:29][CH3:30])=[O:28]