HRID403853

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2777557

6-(Trifluoromethyl)nicotinoyl chloride

C7H3ClF3NO

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID123625862

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O

HCID131731441

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=O)c4ccc(C(F)(F)F)nc4)cc3)ccc2C1=O

HCID131731497

未命名化合物

收率 65%

PROCEDURE

实验过程

The compound of example 210 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 6-trifluoromethyl nicotinoyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ebf32e4aadf04a37a5abeef183fbf577
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(NC1C=CC([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38](C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=[CH:37][CH:36]=1.[F:59][C:60]([F:71])([F:70])[C:61]1[CH:69]=[CH:68][C:64]([C:65](Cl)=[O:66])=[CH:63][N:62]=1>>[CH3:33][CH:31]([CH3:32])[C@H:26]([N:21]1[CH2:20][C:19]2[C:23](=[CH:24][CH:16]=[C:17]([C:38]3[CH:37]=[CH:36][C:35]([NH:34][C:65](=[O:66])[C:64]4[CH:68]=[CH:69][C:61]([C:60]([F:71])([F:59])[F:70])=[N:62][CH:63]=4)=[CH:40][CH:39]=3)[CH:18]=2)[C:22]1=[O:25])[C:27]([O:29][CH3:30])=[O:28]