Pyrrolidine → HCID 53303947, compound

HRID 403855Notes

Reaction equation

[CH3:1][CH:2]([CH3:39])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:37])[C:25]4[CH:30]=[CH:29][C:28]([N:31]5[CH2:36][CH2:35]O[CH2:33][CH2:32]5)=[N:27][CH:26]=4)=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:38])[C:4]([O:6][CH3:7])=[O:5].N1CCCC1>>[CH3:1][CH:2]([CH3:39])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:37])[C:25]4[CH:30]=[CH:29][C:28]([N:31]5[CH2:36][CH2:35][CH2:33][CH2:32]5)=[N:27][CH:26]=4)=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:38])[C:4]([O:6][CH3:7])=[O:5]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 53303945HCID 53303945, compound

Product 1

HCID 53303947HCID 53303947, compoundYield 67%

Procedure

The compound of example 216 was prepared analogous to compound of example 212 by reaction of compound of example 211 with pyrrolidine.

Sources & evidence

ORD record: ord-caee7e7fe2f947d89b71afc9f15c8d2a
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08748426B2

Reaction notes

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