Pyridine → HCID 53303514, compound

HRID 403909Notes

Reaction equation

HRID 403909 reaction equation
NC1C=CC([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=CC=1.[N:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[C:32]1([S:38](Cl)(=[O:40])=[O:39])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.Cl[CH2:43]Cl>>[CH3:24][CH:23]([CH3:25])[C@H:18]([N:12]1[CH2:11][C:10]2[C:14](=[CH:15][C:16]([C:28]3[CH:29]=[CH:30][C:31]([NH:26][S:38]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)(=[O:40])=[O:39])=[CH:43][CH:27]=3)=[CH:8][CH:9]=2)[C:13]1=[O:17])[C:19]([O:21][CH3:22])=[O:20]

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 7369Benzenesulfonyl chlorideHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 53303514HCID 53303514, compound

Procedure

The compound of example 223 (0.250 g, 0.0073 mol) was taken in dichloromethane (5 mL) to which pyridine (0.174 g, 0.00219 mol) was added and stirred for 5 min. To this reaction mixture, benzene sulfonyl chloride was added and the reaction mixture was stirred for about 16 h. After completion of the reaction, the solvent was evaporated to obtain the title compound, which was directly used for preparation of compound of example 285.

Workup

  1. additionwas added
  2. stirringthe reaction mixture was stirred for about 16 h
  3. customAfter completion of the reaction
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-9c5c830b77d448f7aabed6f891dcb910
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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