反应详情

Tert-butyl (6-vinyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylcarbamate (485 mg, 1.76 mmol) was dissolved in 5 mL of THF and 5 mL of water then osmium tetroxide (0.687 mL (4% water solution), 0.0176 mmol) was added and stirred for 5 min. Sodium periodate was added (141, 3.53 mmol) and the reaction was stirred for 2 h. The reaction was then extracted with dichloromethane (3×10 mL), dried over Na2SO4 and concentrated. Purification via MPLC (DCM/MeOH+1% NH4OH) afforded title compound as a tan solid (350 mg, 72% yield).

1. stirringthe reaction was stirred for 2 h
2. extractionThe reaction was then extracted with dichloromethane (3×10 mL)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customPurification via MPLC (DCM/MeOH+1% NH4OH)