反应详情

温度

82.5 °C

The compound of example 329 (288 mg, 0.886 mmol), compound of example 327 (300 mg, 0.738 mmole) and Pd(dppf)Cl2: CH2Cl2 (18 mg, 0.022 mmol) were taken in DMF (5 mL) under an argon atmosphere. To this reaction mixture, 2M solution of Na2CO3 (234 mg, 2.214 mmole, 1.1 mL) was added. The reaction mixture was stirred at 80-85° C. for 1 to 1.5 h. After completion of the reaction, water was added and the product obtained was extracted with ether. The ether layer was washed with water, brine and dried over anhydrous Na2SO4 or anhydrous MgSO4. The solvent was evaporated and the residue obtained was purified by column chromatography (silica gel, 30% ethyl acetate in petroleum ether) obtain the title compound.

1. additionwas added
2. customthe product obtained
3. extractionwas extracted with ether
4. washThe ether layer was washed with water, brine
5. dry with materialdried over anhydrous Na2SO4 or anhydrous MgSO4
6. customThe solvent was evaporated
7. customthe residue obtained
8. customwas purified by column chromatography (silica gel, 30% ethyl acetate in petroleum ether)