Methyl 2-amino-2-phenylacetate hydrochloride → (S)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-2-phenylacetate

HRID 403944Notes

Reaction equation

HRID 403944 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@H:12]([CH:17]([CH3:19])[CH3:18])[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.CO[C:23](=O)[CH:24]([C:26]1C=CC=CC=1)N>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@@H:12]([C:17]3[CH:19]=[CH:26][CH:24]=[CH:23][CH:18]=3)[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 12247454Methyl 2-amino-2-phenylacetate hydrochlorideHCID 131731530(R)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731532(S)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-2-phenylacetate

Procedure

The compound of example 344 was prepared analogous to compound of example 329 by reaction of the compound of example 328 and 2-phenyl glycine methyl ester hydrochloride.

Sources & evidence

ORD record
ord-7846447503074544bf04c858349ea2cb
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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