(R)-3-Methyl-2-(1-oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)iso indolin-2-yl)butanoic acid → (S)-2-(1-Oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)-2-phenylacetic acid

HRID 403946Notes

Reaction equation

HRID 403946 reaction equation
CC(C)[C@@H](N1CC2C(=CC(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)=CC=2)C1=O)C(O)=O.[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][CH:44]=[C:45]([C:48]3[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:67])([F:66])[F:65])[CH:59]=4)=[O:56])=[CH:50][CH:49]=3)[CH:46]=2)[CH2:41][N:40]1[C@@H:68]([C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)[C:69]([O:71]C)=[O:70]>>[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][CH:44]=[C:45]([C:48]3[CH:49]=[CH:50][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:66])([F:65])[F:67])[CH:59]=4)=[O:56])=[CH:52][CH:53]=3)[CH:46]=2)[CH2:41][N:40]1[C@@H:68]([C:73]1[CH:74]=[CH:75][CH:76]=[CH:77][CH:78]=1)[C:69]([OH:71])=[O:70]

Participants

3

Reactant 2

HCID 67306771(R)-3-Methyl-2-(1-oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)iso indolin-2-yl)butanoic acidHCID 131731533(S)-Methyl 2-(1-oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)-2-phenylacetate

Product 1

HCID 67305999(S)-2-(1-Oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)-2-phenylacetic acidYield 82%

Procedure

The compound of example 346 was prepared analogous to compound of example 331 by hydrolysis of the compound of example 345.

Sources & evidence

ORD record
ord-18cc7fe425b44af8940004cfae5695ac
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

Loading…