反应详情

温度

82.5 °C

The compound of example 359 (288 mg, 0.886 mmol), compound of example 357 (300 mg, 0.738 mmol) and Pd(dppf)Cl2: CH2Cl2 (18 mg, 0.022 mmol) were taken in DMF (5 mL) under an argon atmosphere. To this reaction mixture, 2M solution of Na2CO3 (234 mg, 2.214 mmol, 1.1 mL) was added and the reaction mixture was stirred at 80-85° C. for 1 to 1.5 h. After completion of the reaction, water was added to the reaction mixture and the product obtained was extracted with ether. The combined ether layers were washed with water and brine, dried over anhydrous Na2SO4 or MgSO4. The solvent was evaporated and the product was purified by column chromatography (silica gel, 30% ethyl acetate in petroleum ether) to obtain the title compound.

1. additionwas added to the reaction mixture
2. customthe product obtained
3. extractionwas extracted with ether
4. washThe combined ether layers were washed with water and brine
5. dry with materialdried over anhydrous Na2SO4 or MgSO4
6. customThe solvent was evaporated
7. customthe product was purified by column chromatography (silica gel, 30% ethyl acetate in petroleum ether)