Methyl 1-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)cyclopentanecarboxylate → 1-(1-Oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)cyclopentanecarboxylic acid

HRID 403965Notes

Reaction equation

HRID 403965 reaction equation
CC(C)[C@@H](N1CC2C(=CC=C(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)C=2)C1=O)C(O)=O.[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][C:44]([C:48]3[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:67])([F:66])[F:65])[CH:59]=4)=[O:56])=[CH:50][CH:49]=3)=[CH:45][CH:46]=2)[CH2:41][N:40]1[C:68]1([C:73]([O:75]C)=[O:74])[CH2:72][CH2:71][CH2:70][CH2:69]1>>[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][C:44]([C:48]3[CH:49]=[CH:50][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:66])([F:65])[F:67])[CH:59]=4)=[O:56])=[CH:52][CH:53]=3)=[CH:45][CH:46]=2)[CH2:41][N:40]1[C:68]1([C:73]([OH:75])=[O:74])[CH2:72][CH2:71][CH2:70][CH2:69]1

Participants

3

Reactant 2

HCID 67305539Methyl 1-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)cyclopentanecarboxylateHCID 67308300(R)-3-Methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoic acid

Product 1

HCID 673064871-(1-Oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)cyclopentanecarboxylic acidYield 83%

Procedure

The compound of example 370 was prepared analogous to the compound of example 361 by hydrolysis of the compound of example 369.

Sources & evidence

ORD record
ord-98f357c2c896416c93dc201c37b3b93b
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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