HRID403976

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@H](C(=O)O)N1Cc2cc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccc2C1=O

HCID67308300

未命名化合物

结构：COC(=O)[C@H](Cc1ccccc1)N1Cc2cc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccc2C1=O

HCID131731541

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(-c2ccc3c(c2)CN([C@@H](Cc2ccccc2)C(=O)O)C3=O)cc1)Nc1cccc(C(F)(F)F)c1

HCID67307308

未命名化合物

收率 87%

PROCEDURE

实验过程

The compound of example 382 was prepared analogous to the compound of example 361 by hydrolysis of the compound of example 381.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-28426593db674f869a8486b4e35eed48
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

CC(C)[C@@H](N1CC2C(=CC=C(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)C=2)C1=O)C(O)=O.[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][C:44]([C:48]3[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:67])([F:66])[F:65])[CH:59]=4)=[O:56])=[CH:50][CH:49]=3)=[CH:45][CH:46]=2)[CH2:41][N:40]1[C@@H:68]([CH2:73][C:74]1[CH:79]=[CH:78][CH:77]=[CH:76][CH:75]=1)[C:69]([O:71]C)=[O:70]>>[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][C:44]([C:48]3[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:66])([F:65])[F:67])[CH:59]=4)=[O:56])=[CH:50][CH:49]=3)=[CH:45][CH:46]=2)[CH2:41][N:40]1[C@@H:68]([CH2:73][C:74]1[CH:75]=[CH:76][CH:77]=[CH:78][CH:79]=1)[C:69]([OH:71])=[O:70]