HRID404007

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4ccc(C(C)(C)C)cc4)cn3)cc2C1=O

HCID67306402

未命名化合物

结构：CCCCCc1ccc(C(=O)Nc2ccc(-c3ccc4c(c3)C(=O)N([C@H](C(=O)OC)C(C)C)C4)c(C(F)(F)F)c2)cc1

HCID123601898

未命名化合物

PRODUCTS

生成物

结构：CCCCCc1ccc(C(=O)Nc2ccc(-c3ccc4c(c3)C(=O)N([C@H](C(=O)O)C(C)C)C4)c(C(F)(F)F)c2)cc1

HCID70975293

未命名化合物

收率 79%

PROCEDURE

实验过程

The compound of example 430 was prepared analogous to the compound of example 404 by hydrolysis of the compound of example 429.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5af32107ccd14504a612825f1c5e9723
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(C1C=CC(C(NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(O)=O)C4=O)=CC=3)=NC=2)=O)=CC=1)(C)(C)C.[CH3:37][CH:38]([CH3:78])[C@H:39]([N:44]1[CH2:52][C:51]2[C:46](=[CH:47][C:48]([C:53]3[CH:58]=[CH:57][C:56]([NH:59][C:60](=[O:72])[C:61]4[CH:66]=[CH:65][C:64]([CH2:67][CH2:68][CH2:69][CH2:70][CH3:71])=[CH:63][CH:62]=4)=[CH:55][C:54]=3[C:73]([F:76])([F:75])[F:74])=[CH:49][CH:50]=2)[C:45]1=[O:77])[C:40]([O:42]C)=[O:41]>>[CH3:78][CH:38]([CH3:37])[C@H:39]([N:44]1[CH2:52][C:51]2[C:46](=[CH:47][C:48]([C:53]3[CH:58]=[CH:57][C:56]([NH:59][C:60](=[O:72])[C:61]4[CH:66]=[CH:65][C:64]([CH2:67][CH2:68][CH2:69][CH2:70][CH3:71])=[CH:63][CH:62]=4)=[CH:55][C:54]=3[C:73]([F:75])([F:76])[F:74])=[CH:49][CH:50]=2)[C:45]1=[O:77])[C:40]([OH:42])=[O:41]