4-tert-Butylbenzoyl chloride → (S)-Methyl 2-(6-(4-(4-tert-butylbenzamido)-2-methylphenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 404020Notes

Reaction equation

HRID 404020 reaction equation
[C:1]([C:5]1[CH:37]=[CH:36][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:26]=[C:25]4[C:21]([CH2:22][N:23]([C@@H:28]([CH:33]([CH3:35])[CH3:34])[C:29]([O:31][CH3:32])=[O:30])[C:24]4=[O:27])=[CH:20][CH:19]=3)=N[CH:17]=2)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:38](C1C=CC(C(Cl)=O)=CC=1)(C)(C)[CH3:39]>>[C:1]([C:5]1[CH:37]=[CH:36][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:26]=[C:25]4[C:21]([CH2:22][N:23]([C@@H:28]([CH:33]([CH3:34])[CH3:35])[C:29]([O:31][CH3:32])=[O:30])[C:24]4=[O:27])=[CH:20][CH:19]=3)=[C:38]([CH3:39])[CH:17]=2)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 743724-tert-Butylbenzoyl chlorideHCID 131731552(S)-Methyl 2-(6-(5-(4-tert-butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 123966518(S)-Methyl 2-(6-(4-(4-tert-butylbenzamido)-2-methylphenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateYield 82%

Procedure

The compound of example 467 was prepared analogous to the compound of example 403 by reaction of the compound of example 466 with 4-(t-butyl)benzoyl chloride.

Sources & evidence

ORD record
ord-e2bf90ef127e4345bb99e57cb7d921ad
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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