HRID404021

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4ccc(C(C)(C)C)cc4)cn3)cc2C1=O

HCID67306402

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccc(C(C)(C)C)cc4)cc3C)cc2C1=O

HCID123966518

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(NC(=O)c2ccc(C(C)(C)C)cc2)ccc1-c1ccc2c(c1)C(=O)N([C@H](C(=O)O)C(C)C)C2

HCID67305614

未命名化合物

收率 82%

PROCEDURE

实验过程

The compound of example 468 was prepared analogous to the compound of example 404 by hydrolysis of the compound of example 467.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c40df20e187a4aa89e4fadb5408dc2e3
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(C1C=CC(C(NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(O)=O)C4=O)=CC=3)=NC=2)=O)=CC=1)(C)(C)C.[C:37]([C:41]1[CH:74]=[CH:73][C:44]([C:45]([NH:47][C:48]2[CH:53]=[CH:52][C:51]([C:54]3[CH:62]=[C:61]4[C:57]([CH2:58][N:59]([C@@H:64]([CH:69]([CH3:71])[CH3:70])[C:65]([O:67]C)=[O:66])[C:60]4=[O:63])=[CH:56][CH:55]=3)=[C:50]([CH3:72])[CH:49]=2)=[O:46])=[CH:43][CH:42]=1)([CH3:40])([CH3:39])[CH3:38]>>[C:37]([C:41]1[CH:74]=[CH:73][C:44]([C:45]([NH:47][C:48]2[CH:53]=[CH:52][C:51]([C:54]3[CH:62]=[C:61]4[C:57]([CH2:58][N:59]([C@@H:64]([CH:69]([CH3:70])[CH3:71])[C:65]([OH:67])=[O:66])[C:60]4=[O:63])=[CH:56][CH:55]=3)=[C:50]([CH3:72])[CH:49]=2)=[O:46])=[CH:43][CH:42]=1)([CH3:38])([CH3:40])[CH3:39]