Methyl 2-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)propanoate → Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-2-methylpropanoate

HRID 404038Notes

Reaction equation

HRID 404038 reaction equation
NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[CH3:26][C:27]([N:33]1[CH2:41][C:40]2[C:35](=[CH:36][C:37]([C:42]3[CH:47]=[CH:46][C:45]([N+:48]([O-])=O)=[CH:44][CH:43]=3)=[CH:38][CH:39]=2)[C:34]1=[O:51])([CH3:32])[C:28]([O:30][CH3:31])=[O:29]>>[NH2:48][C:45]1[CH:44]=[CH:43][C:42]([C:37]2[CH:36]=[C:35]3[C:40]([CH2:41][N:33]([C:27]([CH3:32])([CH3:26])[C:28]([O:30][CH3:31])=[O:29])[C:34]3=[O:51])=[CH:39][CH:38]=2)=[CH:47][CH:46]=1

Participants

3

Reactant 2

HCID 67306803Methyl 2-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)propanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67307528Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-2-methylpropanoateYield 78%

Procedure

The compound of example 515 was prepared analogous to the compound of example 6 by reduction of the compound of example 514.

Sources & evidence

ORD record
ord-4bc037e6d990495886e9e3cc6a423664
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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