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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404069Generated: October 26, 2026

4-(Trifluoromethyl)benzoyl chloride → Methyl 1-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclobutanecarboxylate

https://huagongshe.com/reaction/404069

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzoyl chlorideHCID 67607—
ReactantMethyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylateHCID 67314591—
Reactant(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 123625862—
ProductMethyl 1-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclobutanecarboxylateHCID 5330300383%

Reaction Steps

The compound of example 579 was prepared analogous to compound of example 97 by reaction of compound of example 574 with 4-trifluoromethyl benzoyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-93c1668ad5e44f11bf06f5d854289b7d
Source noteuspto-grants-2014_06