HRID404082

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67607

Benzoyl chloride, 4-(trifluoromethyl)-

C8H4ClF3O

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID123625862

未命名化合物

结构：COC(=O)[C@H]1CCC[C@H]1N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O

HCID131731584

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H]1CCC[C@H]1N1Cc2ccc(-c3ccc(NC(=O)c4ccc(C(F)(F)F)cc4)cc3)cc2C1=O

HCID131731586

未命名化合物

收率 86%

PROCEDURE

实验过程

The compound of example 597 was prepared analogous to compound of example 97 by reaction of compound of example 592 with 4-trifluoromethyl benzoyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-210745d55ae244aaaa63027084fef336
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C@@H:51]4[CH2:55][CH2:54][CH2:53][C@@H:52]4[C:56]([O:58][CH3:59])=[O:57])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.[F:60][C:61]([F:72])([F:71])[C:62]1[CH:70]=[CH:69][C:65]([C:66](Cl)=[O:67])=[CH:64][CH:63]=1>>[O:50]=[C:47]1[C:48]2[C:44](=[CH:43][CH:42]=[C:41]([C:38]3[CH:37]=[CH:36][C:35]([NH:34][C:66](=[O:67])[C:65]4[CH:69]=[CH:70][C:62]([C:61]([F:60])([F:71])[F:72])=[CH:63][CH:64]=4)=[CH:40][CH:39]=3)[CH:49]=2)[CH2:45][N:46]1[C@@H:51]1[CH2:55][CH2:54][CH2:53][C@@H:52]1[C:56]([O:58][CH3:59])=[O:57]