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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404082Generated: October 30, 2026

4-(Trifluoromethyl)benzoyl chloride → (1S,2R)-Methyl 2-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclopentanecarboxylate

https://huagongshe.com/reaction/404082

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzoyl chlorideHCID 67607—
Reactant(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 123625862—
Reactant(1S,2R)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclopentane carboxylateHCID 131731584—
Product(1S,2R)-Methyl 2-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclopentanecarboxylateHCID 13173158686%

Reaction Steps

The compound of example 597 was prepared analogous to compound of example 97 by reaction of compound of example 592 with 4-trifluoromethyl benzoyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-210745d55ae244aaaa63027084fef336
Source noteuspto-grants-2014_06