Ethyl 5-phenyl-1,3-oxazole-2-carboxylate → (S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenyloxazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoate

HRID 404089Notes

Reaction equation

HRID 404089 reaction equation
[CH3:1][CH:2]([CH3:38])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]4S[C:28]([C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:29][N:30]=4)=[O:25])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5].NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=[O:55])=CC=2)=CC=1.C1(C2OC(C(OCC)=O)=NC=2)C=CC=CC=1>>[CH3:1][CH:2]([CH3:38])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]4[O:55][C:28]([C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:29][N:30]=4)=[O:25])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5]

Participants

4

Reactant 3

HCID 13388477Ethyl 5-phenyl-1,3-oxazole-2-carboxylateHCID 123332092(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenylthiazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 123818773(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenyloxazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoate

Procedure

The compound of example 613 was prepared analogous to the compound of example 611 by reaction of compound of example 6 with ethyl 5-phenyloxazole-2-carboxylate.

Sources & evidence

ORD record
ord-00e74638b2524de492e2dc5a259388af
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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