HRID404100

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID651752

ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate

C11H10N2O3

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ncc(-c5ccccc5)s4)cc3)cc2C1=O

HCID123332092

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O

HCID131731441

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4nnc(-c5ccccc5)o4)cc3)cc2C1=O

HCID123909477

未命名化合物

收率 44%

PROCEDURE

实验过程

The compound of example 625 was prepared analogous to the compound of example 611 by reaction of compound of example 6 with commercially available ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate (Enamine Ltd, Ukraine, Europe).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1b35077aecf403cb2de409e1edcc749
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

[CH3:1][CH:2]([CH3:38])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]4SC(C5C=CC=CC=5)=C[N:30]=4)=[O:25])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5].NC1C=CC([C:46]2[CH:54]=[C:53]3[C:49](C[N:51]([C@@H](C(C)C)C(OC)=O)[C:52]3=[O:55])=[CH:48][CH:47]=2)=CC=1.C1(C2OC(C(OCC)=O)=NN=2)C=CC=CC=1>>[CH3:1][CH:2]([CH3:38])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:18]=[CH:19][C:20]([NH:23][C:24]([C:26]4[O:55][C:52]([C:53]5[CH:54]=[CH:46][CH:47]=[CH:48][CH:49]=5)=[N:51][N:30]=4)=[O:25])=[CH:21][CH:22]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5]