Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404100Generated: October 30, 2026

Ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate → (S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenyl-1,3,4-oxadiazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoate

https://huagongshe.com/reaction/404100

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 5-phenyl-1,3,4-oxadiazole-2-carboxylateHCID 651752—
Reactant(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenylthiazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoateHCID 123332092—
Reactant(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441—
Product(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenyl-1,3,4-oxadiazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoateHCID 12390947744%

Reaction Steps

The compound of example 625 was prepared analogous to the compound of example 611 by reaction of compound of example 6 with commercially available ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate (Enamine Ltd, Ukraine, Europe).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-b1b35077aecf403cb2de409e1edcc749
Source noteuspto-grants-2014_06