1,2-Dimethyl 4-bromobenzene-1,2-dicarboxylate → (5-Bromo-2-(hydroxymethyl)phenyl)methanol

Participants

Reaction Conditions

Reaction Steps

The compound of example 668 (2 g, 7.326 mmol) was taken in dry THF and was added to a slurry of LiAlH4 (1.67 g, 43.95 mmol) in THF cooled to 0° C. The reaction mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with aqueous NaOH solution followed by extraction with ethyl acetate. The solvent was removed by distillation to afford the title compound.

Provenance & Evidence