反应详情

温度

0 °C

The compound of example 668 (2 g, 7.326 mmol) was taken in dry THF and was added to a slurry of LiAlH4 (1.67 g, 43.95 mmol) in THF cooled to 0° C. The reaction mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with aqueous NaOH solution followed by extraction with ethyl acetate. The solvent was removed by distillation to afford the title compound.

1. customThe reaction mixture was quenched with aqueous NaOH solution
2. extractionfollowed by extraction with ethyl acetate
3. customThe solvent was removed by distillation