(2R)-4-[3-(2-Fluoro-3-methoxyphenyl)isoxazol-5-yl]-2-methyl-2-(methylsulfonyl)butanoic acid → (2R)-4-[5-(2-fluoro-3-methoxyphenyl)isoxazol-3-yl]-2-methyl-2-(methylsulfonyl)butanoic acid

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Reaction Steps

The title compound (0.46 g, 95%) was prepared from ethyl(2R)-4-[5-(2-fluoro-3-methoxyphenyl)isoxazol-3-yl]-2-methyl-2-(methylsulfonyl)butanoate (0.50 g, 1.25 mmol) by following the procedure described for the synthesis of (2R)-4-[3-(2-fluoro-3-methoxyphenyl)isoxazol-5-yl]-2-methyl-2-(methylsulfonyl)butanoic acid (Example 1, Step B). MS (GCMS) m/z 372.1 (M+1). 1H NMR (400 MHz, METHONAL-d4) δ1.69 (s, 3H) 2.45-2.56 (m, 2H) 3.14 (d, J=9.95 Hz, 5H) 3.93 (s, 3H) 6.70-6.82 (m, 1H) 7.19-7.30 (m, 2H) 7.37-7.52 (m, 1H).

Provenance & Evidence