HCID 67360452, compound → HCID 58380189, compound

HRID 404318Notes

Reaction equation

HRID 404318 reaction equation
C([O:8][C:9]1[N:14]=[CH:13][C:12]2[CH2:15][CH2:16][C:17]3([CH2:19][CH:18]3[C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:11]=2[CH:10]=1)C1C=CC=CC=1.[H][H]>CCO.[Pd]>[O:8]=[C:9]1[NH:14][CH:13]=[C:12]2[CH2:15][CH2:16][C:17]3([CH2:19][CH:18]3[C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:11]2=[CH:10]1

Participants

5

Reactant 2

HCID 67360452HCID 67360452, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58380189HCID 58380189, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Compound H6.7 (200 mg, 618 μmol) was dissolved in 5 mL EtOH. To this solution was added palladium on carbon (65.8 mg, 618 μmol) and hydrogen was introduced by balloon. The reaction was stirred at room temperature for 1 hour. After the reaction was complete, the catalyst was filtered off and the solvent was removed to provide H6.8 (135 mg, 93.6%). MS ESI (pos.) m/e: 234.2 (M+H)+.

Workup

  1. additionwas introduced by balloon
  2. filtrationthe catalyst was filtered off
  3. customthe solvent was removed
  4. customto provide H6.8 (135 mg, 93.6%)

Sources & evidence

ORD record
ord-5c7d2b64a4e4483a84f5eab0ffd5272c
Source dataset
uspto-grants-2014_06
Patent number
US08748462B2

Reaction notes

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