反应详情

温度

23 °C

To a stirred solution of 4-(5-fluoro-2-methoxypyridin-4-yl)-3-(methoxycarbonyl)benzoic acid T6.2 (0.416 g, 1 mmol) in THF (14 mL) at 0° C. was added borane-THF (3 mL, 3 mmol, 1.0M). The reaction was warmed to 23° C. and stirred for 46 hours. The reaction was then concentrated in vacuo, diluted with 1N HCl and extracted three times with EtOAc. The organic layers were combined, dried over anhydrous MgSO4, and filtered. The organic solvent was removed under reduced pressure, and the product was purified on silica gel (0-40% EtOAc in hexanes) to yield T6.3 as a colorless solid (0.307 g, 77% yield).

1. concentrationThe reaction was then concentrated in vacuo
2. additiondiluted with 1N HCl
3. extractionextracted three times with EtOAc
4. dry with materialdried over anhydrous MgSO4
5. filtrationfiltered
6. customThe organic solvent was removed under reduced pressure
7. customthe product was purified on silica gel (0-40% EtOAc in hexanes)