反应详情

To a stirred solution of methyl 2-(5-fluoro-2-methoxypyridin-4-yl)-5-(hydroxymethyl)benzoate T6.3 (0.307 g, 1 mmol) in THF (11 mL) at −78° C. was added tert-butyl lithium (2 mL, 3 mmol). The resulting mixture was stirred for one hour. The reaction was then quenched with a saturated solution of ammonium chloride and extracted three times with EtOAc. The combined organic layers were dried over anhydrous magnesium sulfate, filtered, and the organic solvent was removed under reduced pressure. The residue was then purified on silica gel (0-40% EtOAc in hexanes) to yield T6.4 as a colorless solid (0.28 g, 84% yield).

1. customThe reaction was then quenched with a saturated solution of ammonium chloride
2. extractionextracted three times with EtOAc
3. dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customthe organic solvent was removed under reduced pressure
6. customThe residue was then purified on silica gel (0-40% EtOAc in hexanes)