反应详情

To a mixture of T9.3 (1.1530 g, 3.079 mmol) and THF (10 mL) at 0° C. was added LAH (1.0 M solution in THF (4.619 mL, 4.619 mmol)). The reaction was stirred for one hour and then carefully diluted with water, extracted with EtOAc, washed with brine, dried over sodium sulfate, filtered, and concentrated to provide T9.4 (0.9050 g, 96.57% yield).

1. extractionextracted with EtOAc
2. washwashed with brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customto provide T9.4 (0.9050 g, 96.57% yield)