反应详情

To a mixture of T13.1 (795 mg, 2230 μmol) and THF (10 mL) at 0° C. was added LAH (1.0 M solution in THF (3345 μL, 3345 μmol)). The reaction was stirred for one hour and then carefully diluted with water and extracted with EtOAc. The combined organic layers were washed with brine and then dried over sodium sulfate, filtered, and concentrated to provide T13.2 (530 mg, 83.0% yield).

1. extractionextracted with EtOAc
2. washThe combined organic layers were washed with brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customto provide T13.2 (530 mg, 83.0% yield)