Thionyl Chloride → HCID 58379746, compound

HRID 404345Notes

Reaction equation

HRID 404345 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[C:10]([CH2:12]O)[CH:9]=[CH:8][C:7]=1[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=1)[CH2:2][CH2:3][CH3:4].S(Cl)([Cl:24])=O>C(Cl)Cl>[CH2:1]([O:5][C:6]1[CH:11]=[C:10]([CH2:12][Cl:24])[CH:9]=[CH:8][C:7]=1[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 58380155HCID 58380155, compound

Product 1

HCID 58379746HCID 58379746, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of T13.2 (530 mg, 1851 μmol) in DCM (15 mL) at 23° C. was added thionyl chloride (270 μL, 3702 μmol). The resulting mixture was stirred overnight and was then concentrated and then purified by silica gel chromatography (0 to 10% EtOAc/hexanes) to provide T13.

Workup

  1. concentrationwas then concentrated
  2. custompurified by silica gel chromatography (0 to 10% EtOAc/hexanes)
  3. customto provide T13

Sources & evidence

ORD record
ord-f4b2619fa6ba4104b07775d78976dae3
Source dataset
uspto-grants-2014_06
Patent number
US08748462B2

Reaction notes

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