Thionyl Chloride → HCID 58379844, compound

HRID 404385Notes

Reaction equation

HRID 404385 reaction equation
[CH3:1][C:2]([CH:6]1[C:18]2[CH:17]=[C:16]([CH2:19]O)[CH:15]=[CH:14][C:13]=2[C:12]2[C:7]1=[C:8]([O:22][CH3:23])[CH:9]=[CH:10][C:11]=2[F:21])([CH3:5])[CH:3]=[CH2:4].S(Cl)([Cl:26])=O>C(Cl)Cl>[Cl:26][CH2:19][C:16]1[CH:17]=[C:18]2[C:13]([C:12]3[C:11]([F:21])=[CH:10][CH:9]=[C:8]([O:22][CH3:23])[C:7]=3[CH:6]2[C:2]([CH3:5])([CH3:1])[CH:3]=[CH2:4])=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 58380014HCID 58380014, compound

Product 1

HCID 58379844HCID 58379844, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 21.8 (40 mg, 128 μmol) in DCM (0.8 mL), was added thionyl chloride (30 mg, 256 μmol). The resulting mixture was stirred at room temperature for 1 hour. Solvent was removed in vacuo to give a residue which was used without purification (40 mg, 94%).

Workup

  1. customSolvent was removed in vacuo
  2. customto give a residue which
  3. customwas used without purification (40 mg, 94%)

Sources & evidence

ORD record
ord-937590881dbc40a89b33a19e492af719
Source dataset
uspto-grants-2014_06
Patent number
US08748462B2

Reaction notes

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