反应详情

温度

32.5 °C

Into a 2 Lt. four necked round-bottomed flask provided with a mechanical stirrer, thermometer socket, reflux condenser etc., are charged 1340 mL of methanol, followed by Erlotinib base 60 g. (Prepared according to the process given in Example-(1) of PCT International Publication No. WO 2007/060691). The reaction mass is warmed to around 40° C. so that Erlotinib base completely dissolves. To this reaction mass, carbon treatment is given and the filtrate is transferred to another 2 Lt. four necked flask. To this solution isopropanolic HCl (HCl content as 100% is 6.12 g) is added in one lot and the reaction mass is stirred at 30-35° C. for about 90 minutes and filtered. The product is washed with fresh methanol and dried the wet cake to get 55.2 g of Erlotinib hydrochloride as a white crystalline powder.

1. customfour necked round-bottomed flask provided with a mechanical stirrer
2. temperaturethermometer socket, reflux condenser etc.
3. custom(Prepared
4. customThe reaction
5. dissolutioncompletely dissolves
6. filtrationfiltered
7. washThe product is washed with fresh methanol
8. customdried the wet cake