反应详情

Tri-n-butyl amine (76.76 g) was added to a solution of emtricitabine hydrochloride (101 g; Example 3) in dichloromethane (450 mL) in 30 minutes at 25° C. to 30° C. The solution was stirred at 25° C. to 30° C. for about 5 hours. The product was filtered, washed with dichloromethane (112.5 mL) and dried under vacuum at 40° C. to 45° C. for about 14 hours.

1. filtrationThe product was filtered
2. washwashed with dichloromethane (112.5 mL)
3. customdried under vacuum at 40° C. to 45° C. for about 14 hours