HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(3-Chloropyridin-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2,3-Dichloropyridine | HCID 16988 | — |
| Reactant | 3-(Trimethylsilyl)aniline | HCID 12488883 | — |
| Product | 1-(3-Chloropyridin-2-yl)piperazine | HCID 11412944 | 86.8% |
Reaction Steps
Compound A-01 can be synthesized according to method 1. Just R1, R2, and R3 of Scheme 1 are respectively —Cl, —H and p-SiMe3. More specifically, compound 1 is 2,3-dichloro-pyridine (2 g); compound 2 is piperazine; compound 3 is 1-(3-chloro-2-pyridyl)piperazine (2.3 g, yield 86.8%); compound 7 is compound 7a-p-(trimethylsilyl)phenyl isocynate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748610B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-38048088bb1a4d56b9915737a4ed7b6c |
| Source note | uspto-grants-2014_06 |