Piperazine → 1-(3-Chloropyridin-2-yl)piperazine

HRID 404552Notes

Reaction equation

HRID 404552 reaction equation
C[Si](C)(C)C1C=C(C=CC=1)N.Cl[C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][N:14]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Cl:19][C:18]1[C:13]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 169882,3-DichloropyridineHCID 124888833-(Trimethylsilyl)aniline

Product 1

HCID 114129441-(3-Chloropyridin-2-yl)piperazineYield 86.8%

Procedure

Compound A-01 can be synthesized according to method 1. Just R1, R2, and R3 of Scheme 1 are respectively —Cl, —H and p-SiMe3. More specifically, compound 1 is 2,3-dichloro-pyridine (2 g); compound 2 is piperazine; compound 3 is 1-(3-chloro-2-pyridyl)piperazine (2.3 g, yield 86.8%); compound 7 is compound 7a-p-(trimethylsilyl)phenyl isocynate.

Workup

  1. customCompound A-01 can be synthesized

Sources & evidence

ORD record
ord-38048088bb1a4d56b9915737a4ed7b6c
Source dataset
uspto-grants-2014_06
Patent number
US08748610B2

Reaction notes

Loading…