HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichloropyridine → 1-(3-Chloropyridin-2-yl)-3-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichloropyridine | HCID 16988 | — |
| Reactant | 2-Methylpiperazine, (R)- | HCID 7330434 | — |
| Reactant | 3-(Trimethylsilyl)aniline | HCID 12488883 | — |
| Product | 1-(3-Chloropyridin-2-yl)-3-methylpiperazine | HCID 22727561 | 93.2% |
Reaction Steps
Compound A-02 can be synthesized according to method 1. Just R1, R2, and R3 of Scheme 1 are respectively —Cl, -Me and p-SiMe3. More specifically, compound 1 is 2,3-dichloro-pyridine (6 g), compound 2 is (R)-2-methylpiperazine, the synthesized compound 3 is 1-(3-chloro-2-pyridyl)-3-methyl-piperazine (38 g, yield about 93.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748610B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-f385eba5336f4f4f9df03d7c1747a478 |
| Source note | uspto-grants-2014_06 |