HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Chloro-3-(trifluoromethyl)pyridine | HCID 589833 | — |
| Reactant | 3-(Trimethylsilyl)aniline | HCID 12488883 | — |
| Product | 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 2777786 | 90.1% |
Reaction Steps
Compound A-07 can be synthesized according to method 1. Just of Scheme 1, R1 is —CF3; R2 is —H; R3 is p-SiMe3. More specifically, compound 1 is 2-chloro-3-(trifluoromethyl)pyridine (2 g); compound 2 is piperazine; the synthesized compound 3 is 1-(3-(trifluoromethyl)-2-pyridyl)piperazine (2.3 g, yield about 90.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748610B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-01b0aba7dbfa4640a549e14c198df1c2 |
| Source note | uspto-grants-2014_06 |