Piperazine → 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine

HRID 404555Notes

Reaction equation

HRID 404555 reaction equation
C[Si](C)(C)C1C=C(C=CC=1)N.Cl[C:13]1[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][N:14]=1.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[F:20][C:19]([F:22])([F:21])[C:18]1[C:13]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 124888833-(Trimethylsilyl)aniline

Product 1

HCID 27777861-[3-(Trifluoromethyl)pyridin-2-yl]piperazineYield 90.1%

Procedure

Compound A-07 can be synthesized according to method 1. Just of Scheme 1, R1 is —CF3; R2 is —H; R3 is p-SiMe3. More specifically, compound 1 is 2-chloro-3-(trifluoromethyl)pyridine (2 g); compound 2 is piperazine; the synthesized compound 3 is 1-(3-(trifluoromethyl)-2-pyridyl)piperazine (2.3 g, yield about 90.1%).

Workup

  1. customCompound A-07 can be synthesized

Sources & evidence

ORD record
ord-01b0aba7dbfa4640a549e14c198df1c2
Source dataset
uspto-grants-2014_06
Patent number
US08748610B2

Reaction notes

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