HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(3-Chloropyridin-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2,3-Dichloropyridine | HCID 16988 | — |
| Reactant | 3-(Trimethylsilyl)aniline | HCID 12488883 | — |
| Product | 1-(3-Chloropyridin-2-yl)piperazine | HCID 11412944 | 86.8% |
Reaction Steps
Compound A-11 can be synthesized according to method 1. Just of Scheme 1, R1 is —Cl; R2 is —H; R3 is m-SiMe3. More specifically, compound 1 is 2,3-dichloro pyridine (2 g); compound 2 is piperazine; the synthesized compound 3 is 1-(3-chloro-2-pyridyl)piperazine (2.3 g, yield about 86.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748610B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-fd218f21c9594b99a64631b3cc2e3aec |
| Source note | uspto-grants-2014_06 |