Piperazine → 1-(3-Chloropyridin-2-yl)piperazine

HRID 404558Notes

Reaction equation

HRID 404558 reaction equation
C[Si](C)(C)C1C=C(C=CC=1)N.Cl[C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][N:14]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Cl:19][C:18]1[C:13]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 169882,3-DichloropyridineHCID 124888833-(Trimethylsilyl)aniline

Product 1

HCID 114129441-(3-Chloropyridin-2-yl)piperazineYield 86.8%

Procedure

Compound A-11 can be synthesized according to method 1. Just of Scheme 1, R1 is —Cl; R2 is —H; R3 is m-SiMe3. More specifically, compound 1 is 2,3-dichloro pyridine (2 g); compound 2 is piperazine; the synthesized compound 3 is 1-(3-chloro-2-pyridyl)piperazine (2.3 g, yield about 86.8%).

Workup

  1. customCompound A-11 can be synthesized

Sources & evidence

ORD record
ord-fd218f21c9594b99a64631b3cc2e3aec
Source dataset
uspto-grants-2014_06
Patent number
US08748610B2

Reaction notes

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