huagongshe.com
HRID404560

反应详情

EQUATION

反应方程式

HRID 404560 的结构方程式

REACTANTS

反应物

2
结构：C[Si](C)(C)c1ccc(N)cc1
HCID10034957

4-trimethylsilylaniline

C9H15NSi

2 次

结构：O=C(O)c1ccc(-c2ncccc2C(F)(F)F)cc1
HCID53426235

4-[3-(Trifluoromethyl)pyridin-2-yl]benzoic acid

C13H8F3NO2

2 次

PRODUCTS

生成物

1
结构：C[Si](C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3C(F)(F)F)cc2)cc1
HCID51349201

未命名化合物

收率 68.3%

PROCEDURE

实验过程

Compound A-04 can be synthesized according to method 2. Just R1 and R3 of Scheme 2 are, respectively, CF3 and p-SiMe3. namely: compound 6 is 4-trimethylsilyl aniline (compound 6a 35 mg); compound 10 is 4-(3-trifluoromethylpyridine-2-yl)benzoic acid (compound 10b); compound 12 is compound A-04 (60 mg, yield 68.3%).

WORKUP

后处理

  1. customCompound A-04 can be synthesized