HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-trimethylsilylaniline → 4-(3-(trifluoromethyl)pyridin-2-yl)-N-(4-(trimethylsilyl)phenyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-trimethylsilylaniline | HCID 10034957 | — |
| Reactant | 4-(3-(Trifluoromethyl)pyridin-2-YL)benzoic acid | HCID 53426235 | — |
| Product | 4-(3-(trifluoromethyl)pyridin-2-yl)-N-(4-(trimethylsilyl)phenyl)benzamide | HCID 51349201 | 68.3% |
Reaction Steps
Compound A-04 can be synthesized according to method 2. Just R1 and R3 of Scheme 2 are, respectively, CF3 and p-SiMe3. namely: compound 6 is 4-trimethylsilyl aniline (compound 6a 35 mg); compound 10 is 4-(3-trifluoromethylpyridine-2-yl)benzoic acid (compound 10b); compound 12 is compound A-04 (60 mg, yield 68.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748610B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-b901d51c217b443f8e604afc263a5c7c |
| Source note | uspto-grants-2014_06 |