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HRID404561

反应详情

EQUATION

反应方程式

HRID 404561 的结构方程式

REACTANTS

反应物

2
结构：C[Si](C)(C)c1ccc(N)cc1
HCID10034957

4-trimethylsilylaniline

C9H15NSi

2 次

结构：O=C(O)c1ccc(-c2ncccc2F)cc1
HCID68110061

4-(3-Fluoropyridin-2-yl)benzoic acid

C12H8FNO2

2 次

PRODUCTS

生成物

1
结构：C[Si](C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3F)cc2)cc1
HCID51349202

未命名化合物

收率 80.23%

PROCEDURE

实验过程

The synthesis method of compound A-08 is similar to example 9. Just R1 and R3 of Scheme 2 are, respectively, F and p-SiMe3. namely: compound 6 is 4-trimethylsilyl aniline (compound 6a 35 mg); compound 10 is 4-(3-fluoro-pyridine-2-yl)benzoic acid (compound 10c); compound 12 is compound A-08 (62 mg, yield 80.23%).

WORKUP

后处理

  1. customThe synthesis method of compound A-08