HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-trimethylsilylaniline → HCID 51349202, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-trimethylsilylaniline | HCID 10034957 | — |
| Reactant | 4-(3-Fluoropyridin-2-yl)benzoic acid | HCID 68110061 | — |
| Product | HCID 51349202 | HCID 51349202 | 80.23% |
Reaction Steps
The synthesis method of compound A-08 is similar to example 9. Just R1 and R3 of Scheme 2 are, respectively, F and p-SiMe3. namely: compound 6 is 4-trimethylsilyl aniline (compound 6a 35 mg); compound 10 is 4-(3-fluoro-pyridine-2-yl)benzoic acid (compound 10c); compound 12 is compound A-08 (62 mg, yield 80.23%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748610B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-9ecc28c31d3a4ab98564d426aa943053 |
| Source note | uspto-grants-2014_06 |